Oral Health Management of Patients at Risk of Medication-related Osteonecrosis of the Jaw
Published March 2017
Under review 2022 (see In development for details)
- Full Guidance (PDF) – provides comprehensive background information, recommendations and practical advice. An accessible version(Word) is also available.
- Guidance in Brief (PDF) – summarises the main recommendations from the full guidance. An accessible version (Word) is also available.
- Guidance for Prescribers and Dispensers (PDF) – highlights the recommendations relevant to those who prescribe and dispense anti-resorptive and anti-angiogenic drugs. An accessible version (Word) is also available.
Also available via the SDCEP Dental Companion website.
NICE has accredited the process used by the Scottish Dental Clinical Effectiveness Programme to produce its Oral Health Management of Patients at Risk of Medication-related Osteonecrosis of the Jaw guidance. Accreditation is valid for 5 years from 15 March 2016. More information on accreditation can be viewed at www.nice.org.uk/accreditation.
NICE accreditation was subsequently renewed in 2021 and is valid until 15 March 2026. Further information about NICE accreditation of SDCEP guidance can be viewed at NICE Accreditation.
A number of supporting tools are included with the full guidance to assist the dental team to implement the guidance recommendations. These are available for download and printing:
- Information Leaflets for Patients – these may be used to provide information to patients prescribed anti-resorptive or anti-angiogenic drugs and as the basis for further discussion:
- Dental advice for patients prescribed anti-resorptive drugs for the treatment of osteoporosis or other non-malignant diseases of bone (PDF). An accessible version (Word) is also available;
- Dental advice for patients prescribed anti-resorptive or anti-angiogenic drugs for the treatment of cancer (PDF). An accessible version (Word) is also available;
- Risk Assessment Flowchart (PDF) – a stand-alone, printable version of the flowchart from Section 3 of the guidance;
- Managing the Health of Patients at Risk of MRONJ (PDF)– a stand-alone, printable version of the flowchart from Appendix 3 of the guidance;
- Powerpoint Slide Set (PowerPoint) – a summary of the key messages from the guidance.
- List of Drugs Associated with MRONJ (PDF)– a current list of the drugs with an MHRA Drug Safety Update for MRONJ.
Printed copies of the Full Guidance and Guidance in Brief are available.
About this guidance
There is an increased risk of oral health complications for patients prescribed anti-resorptive or anti-angiogenic drugs (medication-related osteonecrosis of the jaw, MRONJ). This guidance provides recommendations, advice and information to help dental practitioners manage the routine dental care of patients prescribed these drugs and is an update to the previous SDCEP Oral Health Management of Patients Prescribed Bisphosphonates guidance.
The guidance is aimed primarily at dentists in primary care dental practice and will also be of relevance to the secondary care dental service, those involved in dental education and undergraduate trainees. The guidance is also of relevance to prescribers and dispensers of bisphosphonates and to patients.
The guidance is based on a review of available evidence and the opinion of dental and medical experts and experienced practitioners and has been subject to open consultation prior to finalising for publication. The methodology used for the development of this guidance, including details of the evidence search strategy, evidence appraisals and information about conflict of interests can be found in the Oral Health Management of Patients at Risk of Medication-related Osteonecrosis of the Jaw Guidance Development Methodology (PDF). Further information on the SDCEP guidance development process is available or contact the SDCEP office (firstname.lastname@example.org).
During the development process, potential barriers to the implementation of this guidance were identified. A Guidance Implementation Summary (PDF) of information about these is provided. For further details visit the TRiaDS website.
A multidisciplinary Guidance Development Group, consisting of individuals from a range of branches of the dental and medical professions together with two patient representatives, was convened to develop and write this guidance, assisted by our Programme Development Team.
Review and updating
In line with SDCEP’s standard five-year guidance review period, a scheduled review of the guidance topic commenced in 2022. For further information, see In development.